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Taken together, these findings reinforce the need for clinical trials evaluating antioxidant-based therapies to improve prognosis and clinical outcomes in patients with methylmalonic acidemia and propionic acidemia

However, no inflammatory and catabolic pathways are activated in skeletal muscle at early stages, suggesting that only a prolonged exposure to a pro-inflammatory status and/or additional elements are required to induce muscle wasting (Op den Kamp et al., 2012)

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